DESCRIPTION

Nilotinib sold under the brand name  Tasigna 150mg and its belongs to targeted cancer cells  Tasigna 150mg tablet is anticancer drugs, which prohibits development of the cancer cells.

Tasigna 150mg is a prescription medicine, which sold under the supervision of medical oncologist.  Tasigna 150mg tablet  is also belongs to the class of kinase inhibitors.

TASIGNA INDICATION

Tasigna 150mg tablets is mainly indicated in the conditions like; Chronic and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) resistant or intolerant to prior therapy that included Imatinib in adult patients

MECHANISM OF ACTION

CML: chronic myelogenous leukemia is caused by BCR-ABL oncogene  Tasigna 150mg tablet  (nilotinib) is a kinase inhibitor, which prohibits BCR-ABL kinase activity.  Tasigna 150mg tablets  link to the ATP-bounding site of BCR-ABL protein  Tasigna 150mg inhibits proliferation of murine leukemic cell lines and human cell lines derived from patients with Philadelphia positive CML

PHARMACOKINETIC

ABSORPTION

The bioavailability of Tasigna 150mg tablets are about 50% The time to high plasma concentration of Tasigna 150mg  tablet is occurred within 3 hours after administration.

EFFECT OF FOOD

The effect of drug is increased to 82% when the dose was given 30 minutes after a high fat meal when compared to fasted patient.

DISTRIBUTION

The binding of serum protein of the Tasigna 150mg is approximately 98% The drug nilotinib blood plasma ratio is 0.68

METABOLISM

Tasigna 150mg tablet is metabolized through CYP3A4 mediated oxidation Tasigna 150mg is the prime flowing component in the blood stream

ELIMINATION

The Tasigna 150mg half life period is approximately 17 hours

PRODUCT DETAILS

Ingredients : Nilotinib 
Strength : 150mg 
Category : Anti-neoplastic drug

DOSAGE MANAGEMENT

The usual dose of Tasigna 150mg Tablet should be taken as two times in a day at time intervals of 12 hours. The tablet Tasigna 150mg tablet administrated on an empty stomach. Food should not be taken for at least 1 hour after the dose is taken or 2 hours before the dose is taken 

Tasigna 150mg capsules, should be dispersed in one teaspoon of applesauce for the patients, who are unable to taken through mouth Immediately within 15 minutes this mixture should be taken . concomitant use with hematopoietic growth factors such as erythropoietin or G-CSF is mandatory Also with hydroxyurea or anagrelideDOSAGE IN ADULT PATIENTS WITH PHILADELPHIA POSITIVE CML-CP

The usual dose of the Tasigna 150mg  tablet in this condition is 300mg should be given orally as twice daily.WITH RESISTANT OR INTOLERANT PHILADELPHIA POSITIVE CML-CP AND CML-AP

The recommended dose is 400mg should be administered as orally twice dailyIN PEDIATRICS

The usual dose for child 230mg/m2 should be administred orally twice daily The maximum dose of Tablet Tasigna 150mg tablet is 400mg.

SIDE EFFECTS

TASIGNA SIDE EFFECTS 

SKIN

Rash, Pruritus, alopecia, dry skin

GIT

Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia

NERVE SYSTEM

Headache, dizziness

GENERAL

Fatigue, pyrexia, asthenia, peripheral edema, face edema

MUSCLE

Myalgia, arthralgia, muscle spasm, pain in extremity, back pain

PULMONARY

Cough, oropharyngeal pain, dyspnea

INFECTIONS & INFESTATIONS

Nasopharyngitis, upper respiratory tract infection, influenza, gastroenteritis

EYE

Eyelid edema, periorbital edema

PSYCHIATRIC

Insomnia

VASCULAR

Hypertension

PREGNANCY & LACTATION

Pregnancy category: D Tasigna tablet avoid during pregnancy condition and women who become pregnant Tasigna 150mg tablet not recommended in breastfeeding mothers

CONTRAINDICATION

Tasigna 150mg tablet do not used in the patients who are having; Hypokalemia Hypomagnesemia Long QT syndrome

STORAGE

Stored at 68°F to 77°F (20°C to 25°C) keep the cartoon away from heat, moisture and light

MISSED DOSE

If patients missed to take the dose of Tasigna 150mg tablet should be take within the time, or the missed dose should be skipped and follow the next dosing schedule.

CONTACT DETAILS

EMAIL: millionhealthpharmaceuticals@gmail.com

PHONE NO: +91-9940472902

WEBSITE : https://millionpharma.com/nilotinib-150mg.php

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